DNA Methylation Profiling Services

Our Epigenomics Profiling Services helps you study DNA methylation (5mC) and methylation variants (5hmC). Our experienced scientists will guide you to the best solution according to your needs, depending on whether you want to analyze DNA methylation at genome-wide or gene specific scales. They will process the arrays or generate meaningful libraries for DNA sequencing and deliver high quality data. Our bioinformatic experts will closely work with you to provide standard and customized analysis with comprehensive publication-ready figures.

Infinium MethylationEPIC Array Service V2

• Cost-effective solution with rapid turnaround time
• Over 930,000 CpGs detected in human samples at single nucleotide resolution
• Quantitative interrogation of CpG, non-CpG, and CHH sites
• Differential methylation analysis using our bioinformatics tools

Reduced Representation Bisulfite Sequencing (RRBS) Service

• Robust and cost-effective solution with reliable results
• Unique technology enables low DNA inputs down to 25ng
• Accurate analyses with UDIs and UMIs
• Up to 7 million CpGs detected in human samples at single nucleotide resolution
• Detection of methylation patterns in CpG-rich regions across the genome including promoters and CpG islands
• Differential methylation analysis using our bioinformatics tools
• Suitable for epigenetic biomarker discovery

Whole Genome Bisulfite Sequencing (WGBS) or Enzymatic Methylation(EM-seq) Service

• Very powerful solution for genome-wide biomarker discovery using bisulfite or enzymatic conversion
• Evaluation of methylation status of nearly every CpG sites of the entire genome at single nucleotide resolution
• Detection of global methylation patterns including in low CpG-density regions and outside of CpG islands
• Identification of regions or even loci with differential methylation levels between groups using our bioinformatics tools

Custom Targeted Methyl-seq

• Focus on DNA methylation analysis of pre-defined regions with single nucleotide resolution
• Custom hybridization capture approach with enzymatic conversion
• Enhanced accuracy, sensitivity and specificity with high coverage while reducing overall cost

Human Methylome

Watch our webinar:

Cost-Effective Genome Wide DNA Methylation Analysis using Twist Hybrid-Capture Methylome Panel

• NGS service assay for comprehensive DNA methylation profiling in human samples from solid or liquid biopsy
• Optimal biomarker discovery tool for cancer, neurodegenerative, cardiovascular and metabolic diseases
• High coverage for more than 3.89 million methylation sites (~9 million CpGs at single strand level)